GLP-1R-knockout IBD-model mice also showed the abnormal proliferation of microbial species in their feces and were more prone to intestinal damage, whereas the GLP-1 receptor agonist Exendin-4 and human GLP-1 analog liraglutide potentially reduced colonic inflammation through immunomodulation (Zatorski et al., 2019). Here, GLP1R is linked to inflammatory bowel disease.