IL10 and irritable bowel syndrome: (Sudha et al., 2018; Madempudi et al., 2019) demonstrated that B. coagulans Unique IS2 was effective in relieving IBS-associated symptoms, such as abdominal pain, bloating, urgency, and straining, in improving stool consistency, and in increasing the serum anti-inflammatory factor IL-10 in children and adults with acceptable tolerability.