Overexpression of ACE2 through Ad-ACE2 infusion in COPD induced Wistar rats was shown to lead to significant attenuation of the COPD inflammatory process through the reduction of oxidative stress and the inhibition of NF-κB and p38 MAPK pathway activation (Xue et al., 2014). This evidence concerns the gene ACE2 and chronic obstructive pulmonary disease.