(24), irradiated Kunming mice received SOD-TAT, a fusion protein of the HIV-1Tat protein transduction domain and hCuZn-SOD, which significantly enhanced the pulmonary antioxidant ability and ameliorated radiation-induced pulmonary fibrosis compared with irradiated mice treated with amifostine and irradiated mice without treatment. The gene discussed is SOD1; the disease is pulmonary fibrosis.