MetaCore pathway analysis of the two cohorts using DEGs showed additional significant information beyond those already found by the gene set enrichment analyses, such as the enrichment in cell-surface receptors associated with the crosstalk between the epithelial malignant cell compartment and the tumor stroma (e.g., IGF1-R, FGF3-R, HGF-R, IBP-4) in LumB tumors and the activation of Wnt signaling in HER2E, with overexpression of several members of the Wnt family and Frizzled. The gene discussed is IGFBP4; the disease is neoplasm.