It was found that AC095057.3 acted as a protective factor and its associated mRNA was also a protective factor for PAAD, among which EID2B, IRX2, CELF3, ACTL6B, SPTBN4, CIRBP, and SGSM1 were statistically significant mRNAs with better prognosis in PAAD. Here, CIRBP is linked to pancreatic adenocarcinoma.