According to the 2010 World Health Organization (WHO) classification criteria (10), tumor grade is defined numerically by the proliferative indicator Ki-67, in which low-grade (grade 1 (G1)) tumors have a Ki-67 index from 0% to 2%, intermediate-grade (G2) tumors have a Ki-67 index from 3% to 20%, and high-grade (G3) tumors have a Ki-67 index greater than 20%. This evidence concerns the gene MKI67 and neoplasm.