Previous studies indicated that NRAGE had a potential association with β-catenin in the formation of radioresistance in ESCC (14), so we detected protein expression in canonical Wnt signaling pathway, namely, β-catenin, phosphorylation of β-catenin (p-β-catenin), Gsk-3β, phosphorylation of Gsk-3β (p-Gsk-3β), and CyclinD1. Here, MAGED1 is linked to esophageal squamous cell carcinoma.