MAGED1 and esophageal squamous cell carcinoma: Comprehensively, the current results confirmed that IR may cause the upregulation of NRAGE, which could accumulate NRAGE to promote nuclear translocation, and triggered β-catenin nuclear accumulation to induce proliferation and anti-proptosis of the ESCC cells, enhance invasiveness and migration capability and cell cycle rearrangement, and promote decreased radiosensitivity (Figure 6S).