MAGED1 and cancer: Initially, NRAGE was reported as a cancer suppressor gene, which promotes cell apoptosis via binding to p75 neurotrophin receptor (P75NTR) (16, 17), Che-1 (18), XIAP-TAK1-TAB1 (19), and UNC5H1 (20) and inhibits proliferation (21) and angiogenesis (22).