Profoundly, in the present study, with further analysis, we found the close-knit pertinence between NRAGE and β-catenin in the clinical setting, in which NRAGE protein expression level, especially for NRAGE nuclear protein, was negatively correlated to short-term efficacy and long-term survival of patients with ESCC receiving radical RT (Tables 1, 2). The gene discussed is MAGED1; the disease is esophageal squamous cell carcinoma.