The present results indicated that the levels of DNMT3B, NSUN6, NSUN7 and YBX2 mRNA were significantly decreased while the levels of DNMT1, DNMT3A, NSUN2, NSUN3, NSUN5 and YBX1 mRNA were significantly increased in PAAD patients (Figures 2A, B). This evidence concerns the gene DNMT1 and pancreatic adenocarcinoma.