Endoscopic tumor length (P = 0.034), tumor location (P = 0.024), clinical T stage (P <0.001), hemoglobin (P = 0.001), preoperative CEA (P <0.001), and LDL-C (P <0.001) were significantly different between the training and external validation cohorts. This evidence concerns the gene CEACAM5 and neoplasm.