However, studies on FBN2 have focused on its methylation, and aberrant methylation of FBN2 has been found in breast cancer, non-small cell lung cancer, and esophageal squamous cell carcinoma (31–33), and the promoter region of the FBN2 gene has been repeatedly reported to be hypermethylated in several types of cancer. The gene discussed is FBN2; the disease is cancer.