FBN2 and esophageal squamous cell carcinoma: However, studies on FBN2 have focused on its methylation, and aberrant methylation of FBN2 has been found in breast cancer, non-small cell lung cancer, and esophageal squamous cell carcinoma (31–33), and the promoter region of the FBN2 gene has been repeatedly reported to be hypermethylated in several types of cancer.