Tumor-normal and inter-tumor analyses of protein expression data highlighted multiple aberrantly-expressed protein targets in key signaling pathways, including PDGFRB, CDK6, ERBB2, and EGFR (Figures 2, 3) whose protein overexpression in HCC tumors are also validated by IHC data from the Human Pathology Atlas (Figure S7). This evidence concerns the gene ERBB2 and hepatocellular carcinoma.