Proteomic analyses enabled us to identify new potentially targetable overexpressed proteins that may correspond to limited driver alterations, such as PDGFRB, ERBB2/3, EGFR and FGFR4 kinases upregulated in HCC tumors arising from no genomic driver alterations, as well as the non-kinase proteins such as MFAP5, HMCN1, EGFL7 and FHL1. This evidence concerns the gene HMCN1 and hepatocellular carcinoma.