Overall, we identified 100 non-kinase DGIdb druggable proteins that were significantly overexpressed (FDR < 0.05) in both HCC cohorts, including POSTN, CYP3A5, ANXA3, ENO2, and VCAM1 (Figure 2C and Figure S3). This evidence concerns the gene CYP3A5 and hepatocellular carcinoma.