In this study, we sought to report a detailed integrative analysis of multi-omics to determine the subgroups of immunophenotypes of ccRCC based on the expression levels of PD-1/IFN-γ and relative contents of infiltrating immune cells, and subsequently identify the key molecules of the DEGs-hub responsible for driving the formation of high/low cytotoxic tumor micro-environment in ccRCC patients with better/poorer overall survival. This evidence concerns the gene IFNG and neoplasm.