After the following univariate Cox regression analysis, lasso regression analysis and multivariate logistic regression analysis, we ultimately determined 5 critical genes (C17orf66, PAEP, WNT2, IRF4, RUFY4) were significantly associated with the prognosis of ccRCC patients in the training group (Figures 14A, B). This evidence concerns the gene IRF4 and nonpapillary renal cell carcinoma.