Generally, BRAF mutations commonly present in human cancers with an 8% incidence in all human cancers, predominantly in hairy cell leukemia (100%) (14), melanoma tumors (40%–50%) (15–17), thyroid carcinoma (10%–70%, based on the histologic classification) (18, 19), colorectal cancer (10%) (20, 21), and rarely in lung cancer (1%–2%) (11, 22). The gene discussed is BRAF; the disease is cancer.