PDK2 and cancer: Of the relatively few studies demonstrating that chemotherapy agents used in the current treatment regimens in breast carcinomas cause metabolic reprogramming in cancer cells Desbats MA et al. presented that ACs induce increased glycolysis, GLUT1 and glutaminase level whereas taxanes induce elevation in glycolysis, in lactate dehydrogenase A (LDHA), pyruvate kinase M (PKM2), pyruvate dehydrogenase kinase 2 (PDK2) (inhibitor of pyruvate dehydrogenase complex), glutamine uptake, fatty acid synthase (FASN), mitophagy, mitochondrial mass and oxidative phosphorylation (OXPHOS) (39).