RAD51 and retinoblastoma: Similarly, functional genomics and transcriptomic analysis of retinoblastoma tumors showed the DNA repair proteins RAD51 and BRCA1 to be deregulated, leading to evaluation of the combination of topotecan, a DNA-damaging drug, with a specific small molecule inhibitor of RAD51, which resulted in synergistic in vitro and in vivo antitumor effects (112).