Recently, it has been reported that TIM-4 is specifically expressed in subcutaneous panniculitis T-cell lymphoma (SPTCL) malignant cells, indicating that TIM-4 may be a potential novel marker for SPTCL (34).Indeed, TIM-4 has been reported as a potential target for cancer diagnosis and therapy (35).Besides, TIM-4 is detected in several kinds of cancer including glioma, colorectal cancer, parapharyngeal liposarcoma, and so on. The gene discussed is TIMD4; the disease is subcutaneous panniculitis-like T-cell lymphoma.