The results of hub targets network indicated that 62 hub targets (SRC, MAPK1, MAPK3, STAT3, LCK, PIK3CA, PIK3R1, EGFR, FYN, AKT1, HSP90AA1, RAC1, PTPN11, GRB2, LYN, RELA, MAPK14, IL2, RHOA, HRAS, PTK2, JUN, JAK1, ESR1, STAT5A, TP53, EP300, CTNNB1, STAT1, CREBBP, NRAS, STAT5B, FOS, MYC, MAPK8, VEGFA, PTK2B, SYK, JAK2, NR3C1, NFKBIA, PRKCD, MAP2K1, CDC42, HDAC1, PRKCA, PRKCZ, AR, CCND1, RPS6KB1, HIF1A, RAF1, ITGAV, SFN, ITGB1, ITGB3, ABL1, PPP2CA, IL6, TNF, RXRA, and NCOR2) might be the most important targets of HMMCR for NSCLC. Here, TNF is linked to non-small cell lung carcinoma.