The intensity medians of CD4 and CD8 from seven normal tissues, 35 adenoma tissues, and 9 carcinoma tissues are statistically summarized in Figure 4E, which indicates that the CD4 and CD8 staining intensities in adenoma and carcinoma were significantly higher than those in normal, whereas the two immune-responsive signals in adenoma were much higher than those in carcinoma. This evidence concerns the gene CD8A and adenoma.