M1 macrophages serve as the key defense in tumor suppression by stimulating the immune system to express high levels of pro-inflammatory cytokines like IL-1, IL-6, and IL-12 (28), and both by inducting T helper type-1 (Th1) cell maturation and promoting inducible nitric-oxide synthase (iNOS) production (29). The gene discussed is IL6; the disease is neoplasm.