High LAGE3 expression was significantly associated with poor prognosis in HCC cases and was correlated with different clinical features including T stage I/II, pathologic stage I/II, with tumor of tumor status, R0 of residual tumor, AFP no more than 400 ng/mL, albumin more than 3.5 g/dl, Child-Pugh grade A, prothrombin time no more than 4 seconds, and with vascular invasion. The gene discussed is LAGE3; the disease is hepatocellular carcinoma.