LAGE3 and hepatocellular carcinoma: To further verify the functions of LAGE3 on HCC cell lines, we first examined the expression of LAGE3 in three HCC cell lines (HepG2, HuH-7 and MHCC97H), and the results showed that the expression of LAGE3 was significantly higher in HCC cells than that in the normal hepatic cell line (L02) (Figure 7A).