EGF and cancer: We speculate that the reasons may be that, firstly, more large platelets are involved in the neoplastic consumed, thereby speeding up the progression of the tumor (23); secondly, the degree of platelet activation affects various effector factors, such as Vascular Endothelial Growth Factor (VEGF), Epidermal Growth Factor (EGF), transforming growth factor-beta (TGFβ), Platelet-derived growth factor (PDGF), and Interleukin-6 (IL-6), that impact vascular maturation in the tumor microenvironment and mediate the invasion of cancer cells (24), which are associated with survival in MDS.