We speculate that the reasons may be that, firstly, more large platelets are involved in the neoplastic consumed, thereby speeding up the progression of the tumor (23); secondly, the degree of platelet activation affects various effector factors, such as Vascular Endothelial Growth Factor (VEGF), Epidermal Growth Factor (EGF), transforming growth factor-beta (TGFβ), Platelet-derived growth factor (PDGF), and Interleukin-6 (IL-6), that impact vascular maturation in the tumor microenvironment and mediate the invasion of cancer cells (24), which are associated with survival in MDS. This evidence concerns the gene VEGFA and cancer.