P4HA3 and malignant colon neoplasm: To further verify whether P4HA3 overexpression affects the effect of miR-1266-3p on the growth ability of colon cancer, we designed three groups in SW480 and HT29 cells, miR-NC+Vector group, miR-1266-3p mimics+Vector group, and miR-1266-3p+P4HA3 group, respectively.