CEACAM5 and neoplasm: Huang et al. (2020) have also revealed that CA19-9 has higher AUC than CEA for LNM assessment in gastric cancer. These findings parallel the results displayed in Tables S4 of our study. In addition, the ratios and cut-off value of tumor markers were screened to develop predictive models, which could achieve AUC 0.721 and 0.758 in internal test cohort and external test cohort, respectively. Our model showed better performance than the clinical features model in previous study (Training cohort of previous study: AUC = 0.7127, Validation cohort of previous study: AUC = 0.7075) (Li et al., 2020).