HMOX1 and Parkinson disease: Current evidence suggests that oxidative stress is related to the pathogenesis of PD (Dionísio, Amaral & Rodrigues, 2021), and increased uperoxide dismutase (SOD), nuclear factor erythroid-2 related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) signaling in the nervous system can reduce oxidative stress related to nerve damage (Nitti et al., 2018).