It has been reported that basal NLRP3 inflammasome activation is increased in individuals with obesity and type 2 diabetes [25] and thus, it is plausible that we did not see an effect of C8 MCT oil supplementation due to our participants being young and healthy; a certain level of innate immune activation must be present in order for adequate protection of the host. The gene discussed is NLRP3; the disease is obesity due to melanocortin 4 receptor deficiency.