However, in contradiction to this theory, our group has also found no effect of both acute and short-term (14 days) elevated blood βHB by ketone monoester (an agent known to increase circulating βHB more robustly than C8 MCT oil) on NLRP3 inflammasome activation in the basal state in individuals with obesity [26, 27]. The gene discussed is NLRP3; the disease is obesity disorder.