NLRP3 and obesity due to melanocortin 4 receptor deficiency: However, in contradiction to this theory, our group has also found no effect of both acute and short-term (14 days) elevated blood βHB by ketone monoester (an agent known to increase circulating βHB more robustly than C8 MCT oil) on NLRP3 inflammasome activation in the basal state in individuals with obesity [26, 27].