AIM2 and parasitic infectious disease: Melanoma deficiency factor 2 (AIM2) is an interferon-inducible gene that is encoded on chromosome 1 in humans, and that is expressed at high levels in leukocytes in the peripheral blood, small intestine, and spleen [5] AIM2 orchestrates inflammatory responses and cell death upon parasitic infection [6, 7], but its role in oncogenic contexts remains to be clarified.