in addition, By regulating the dynamic balance of mitochondria, AIM2 can promote the activation of ERK by extracellular growth factor, promote the phosphorylation of Dynamin related protein 1 (DRP1), and be recruited to mitochondria to cause mitochondrial division, thus leading to the proliferation of tumor cells and drug resistance of tumor cells [15, 16] These reports further confirm that AIM2 regulates MAPK signaling pathway in no-small cell lung cancer(NSCLC). This evidence concerns the gene DNM1L and small cell lung carcinoma.