Interestingly, we observed that the high-risk groups were enriched in the pathways related to hypoxia and tumor process, including glycolysis, angiogenesis, hypoxia, TGF beta signaling, mitotic spindle, TNFA signaling via NF-kB, and epithelial mesenchymal transition (Figure 6). The gene discussed is NFKB1; the disease is neoplasm.