Broadly, DM has been classified into two categories, type I: insulin-dependent diabetes mellitus (IDDM), the cause is an absolute deficiency of insulin secretion, and type II: non-insulin-dependent diabetes mellitus (NIDDM), the cause is a combination of resistance to insulin action and an insufficient compensatory insulin secretory response (3, 4). The gene discussed is INS; the disease is type 1 diabetes mellitus.