TP53 and ischemic stroke: Figure 7(a) shows that CA acts on six stroke targets (e.g., TP53) and 42 PPI partners (e.g., PTGS2), suggesting its possible MOA. Indeed, it has been reported that the proallele of TP53 is related to vascular repair and has the ability to functionally recover from stroke [53]. In addition, a previous in vivo study demonstrated that knockdown of PTGS2 expression could repress the NF-κB signaling pathway, which inhibits apoptosis and promotes proliferation, migration, and angiogenesis of endothelial progenitor cells, thus providing a protective effect in mice with ischemic stroke [39].