CASP1 and pneumonia: In our study, we compared the NLRP3-KO-MCAO and WT-MCAO groups and found that after NLRP3 KO, decreases in the downstream molecules of NLRP3 (caspase-1, IL-1β, and IL-18), a reduction in the cerebral infarction volume and the alleviation of MCAO-induced pneumonia were observed, including edema of the lung interstitium and the infiltration of inflammatory cells in the lung interstitium, suggesting that in addition to the protective effect of NLRP3 KO on lung tissue, improvements in brain injury also protected lung tissue.