Analytic results of the ROC curve (Figure 6) presented a high discrimination ability of each hub gene in the onset of AD (COX5A: AUC = 68.7%; NDUFAB1: AUC = 74.4%; SDHB: AUC = 69.3%; UQCRC2: AUC = 72.9%; and UQCRFS1: AUC = 66.8%). This evidence concerns the gene NDUFAB1 and Alzheimer disease.