AKR1B1 and diabetes mellitus: Mao Xiaoming et al. found that quercetin can inhibit the activity of aldose reductase in the diabetic kidney by measuring the urinary protein in the kidney tissue of experimental diabetic rats, and early application can prevent or delay the occurrence of diabetes [20]; in the research on the protective mechanism of quercetin on the kidneys of diabetic rats, it was found that quercetin can improve oxidative stress and have anti-inflammatory effects, thereby exerting a protective effect on early diabetes [21].