CD4 and specific granule deficiency: The results of the GO analysis showed that the biological processes involved in AA treatment with SGD were mainly inflammatory response, immune response, oxidation-reduction process, etc. Previous studies showed that SGD had anti-inflammatory and immunomodulatory effects, inhibiting the production of prostaglandin E2 (PGE2), nitric oxide (NO), and interleukin-6 (IL-6) [25], as well as regulating the ratio of CD4+CD25+Foxp3+ regulatory T cells [26].