For example, Radix Bupleuri extracts include in the prescription exhibited various biological activities (e.g., anti-inflammatory, neuroprotective, and immunomodulatory effects) [50] that can ameliorate depression symptoms by increasing serum levels of Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF) [51]. This evidence concerns the gene BDNF and depressive symptom measurement.