For example, Radix Bupleuri extracts include in the prescription exhibited various biological activities (e.g., anti-inflammatory, neuroprotective, and immunomodulatory effects) [50] that can ameliorate depression symptoms by increasing serum levels of Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF) [51]. The gene discussed is BDNF; the disease is major depressive disorder.