PTGS2 and diabetic cardiomyopathy: In research about diabetic cardiomyopathy (DCM), mesenchymal stem cell (MSC) infusion in rats was prove to induce macrophages towards the M2 phenotype significantly; however, after being pretreated with a COX-2 inhibitor, it failed with this function interestingly, and such consequence could be reversed by prostaglandin E2 (PGE2) adding [45].