Dynamic equilibrium exists as the determinant of tumor immunogenicity, including the balance between infiltration of effectors (activated CD8+/CD4+ T-cells and T effector memory (Tem) cells) and suppressors (regulatory T (Treg) cells and myeloid-derived suppressor cells (MDSCs)), the dominating type of T helper cells (Th1 and Th2), and the expression of co-stimulators and co-inhibitors [3]. Here, CD8A is linked to neoplasm.