Interleukin-6 (IL-6) is a critical mediator of HCC development [2] and is involved in the regulation of cancer stem cell proliferation, differentiation, invasion, metastasis, and angiogenesis through a number of signaling pathways, such as STAT3 signaling, which drives cancer progression and metastasis [3]. The gene discussed is IL6; the disease is hepatocellular carcinoma.