ACTN3 and atopic asthma: Meanwhile, the ACTN3 locus (index SNP: rs540874, r2 = 0.03 for rs117996675) was reported as a significantly shared locus (Pmeta = 4.09 × 10–9) by meta-analysis for cross-trait associations between non-atopic asthma and BMI, indicating that our SNP (rs117996675) interacts with BMI to affect asthma, likely through ACTN3 (Zhu et al., 2020).