LAMC2 is the only laminin gene found to have mutations in EBS with CAS, with just five pathogenic variants described in previous reports, (Schneider and Muehle, 2008; Hammersen et al., 2016; Mariath et al., 2020), making LAMC2 the rarest gene underlying the disorder. This evidence concerns the gene LAMB2 and epidermolysis bullosa simplex.