Most cases of EBS are caused by dominant mutations of KRT5 (keratin 5), KRT14 (keratin 14), and KLHL24, with a few cases linked to recessive variants of PLEC, KRT5, KRT14, and other genes (Fine et al., 2014; Has et al., 2020b; Mariath et al., 2020). This evidence concerns the gene KRT5 and epidermolysis bullosa simplex.