Pathogenic variants in LDLR, APOB, PCSK9, and APOE are known to cause autosomal dominant familial hypercholesterolaemia (FH), but such mutations are found in only ∼40% of individuals with the clinical diagnosis of FH (Taylor et al., 2010; Motazacker et al., 2012; Futema et al., 2013; Nordestgaard et al., 2013; Mariano et al., 2020). This evidence concerns the gene PCSK9 and familial hyperaldosteronism.