HIF-1α, for example, can recruit myeloid-derived suppressor cells, regulatory T-cells, tumour-associated macrophages with immunosuppressive properties, as well as limit cytotoxic T-lymphocyte invasion (Corzo et al., 2010; Doedens et al., 2010; Imtiyaz et al., 2010; Barsoum et al., 2014). The gene discussed is HIF1A; the disease is neoplasm.