For instance, methylalpinumisoflavone (MF) (PubChem CID: 15596285), a flavonoid isolated from Lanchocarpus glabrescens, demonstrates a strong anti-cancer effect on T47D cells by suppressing HIF-1 and targets genes including CDKN1A, VEGF, and GLUT-1 in T47D cells (Liu et al., 2009). The gene discussed is HIF1A; the disease is cancer.