H19 and neoplasm: By contrast, Qi et al. and Li et al. found that H19 was overexpressed in tumor samples and played an oncogenic role by promoting cell proliferation, migration, and invasion and reducing apoptosis, which ultimately led to increased tumor size, invasion of the optic nerve, and choroidal infiltration; this resulted in a shorter OS (p = 0.006), and the H19 expression level emerged an independent prognostic factor (p < 0.001) (Li et al., 2018; Qi et al., 2019).