In 2019, Wan et al. (Wan et al., 2019) reported that miR-25-3p, which plays an oncogenic role in other cancers such as renal tumors, triple-negative breast cancer, melanoma, and non-small cell lung cancer, also holds negative implications in the case of RB; miR-25-3p promotes tumor malignancy by enhancing proliferation, migration, EMT, in vitro cell invasion, and in vivo tumor formation, all of which increase Akt phosphorylation by suppressing phosphatase and tensin homolog (PTEN). Here, PTEN is linked to melanoma.