AKT1 and neoplasm: Xing et al. (Xing et al., 2018) demonstrated that hsa_circ_0001649 was also underexpressed in RB, and that this favored tumorigenesis by regulating cell proliferation and apoptosis through the Akt/mTOR signaling pathway; moreover, the circRNA downregulation was found to be correlated with increased tumor size, more advanced clinical stage, and shorter OS (p = 0.005), demonstrating the potential usefulness of this circRNA as a prognostic biomarker and therapeutic target in RB.