PTEN and cancer: In 2019, Wan et al. (Wan et al., 2019) reported that miR-25-3p, which plays an oncogenic role in other cancers such as renal tumors, triple-negative breast cancer, melanoma, and non-small cell lung cancer, also holds negative implications in the case of RB; miR-25-3p promotes tumor malignancy by enhancing proliferation, migration, EMT, in vitro cell invasion, and in vivo tumor formation, all of which increase Akt phosphorylation by suppressing phosphatase and tensin homolog (PTEN).