Another miRNA that potently affects the prognosis of patients with RB is miR-485 (Lyu et al., 2019b); miR-485 was underexpressed in patient samples and RB cell lines and this downregulation influenced not only cell proliferation, migration, and invasion, but also apoptosis, chemoresistance, and EMT through Wnt3, which were all increased when the miRNA was downregulated. Here, WNT3 is linked to retinoblastoma.