Zhao and Cui (Zhao and Cui, 2019) demonstrated that miR-361-3p was markedly downregulated in RB tissues, RB serum, and RB cell lines as compared with the levels in normal retinal tissues and normal serum, and that the miRNA functions in suppressing tumorigenesis and progression by acting on the sonic hedgehog (SHH) signaling pathway; this is the opposite of what occurs in cervical cancer, where miR-361-3p has been shown to serve as an oncogene in cancer progression by enhancing cell proliferation and invasion. Here, SHH is linked to retinoblastoma.