In ESCC, lncRNAs, such as ZFAS1 (Li et al., 2019), CASC9 (Liang et al., 2018), GHET1 (Liu et al., 2017), TUSC7 (Chang et al., 2018), and FAM201A (Mingqiu Chen et al., 2018), have been suggested to involve in regulating ESCC epithelial–mesenchymal transition (EMT), metastasis, chemosensitivity, and radiosensitivity. This evidence concerns the gene GHET1 and esophageal squamous cell carcinoma.