TMEM37 and infection: (h)GSH accumulation coincided with the upregulation of PR1, PR10 (Figures 7, 10), 7RA84 (peroxidase), and Hsr203J (hypersensitivity response marker) expression in sym33-3 mutant nodules relative to wild-type nodules, as well as manifestations of other defense responses, such as suberinization, increased unesterified pectin deposition in infection threads walls, and increased cell wall material deposition around the vacuole (Ivanova et al., 2015; Tsyganova et al., 2019b).