In LSG from SS-patients with LFS compared to sicca controls, we found 3 miRNAs differentially expressed (hsa-miR-769-5p, hsa-miR-493-5p and hsa-miR-181d-5p), implicated in regulating 4 genes encoding for glycosyltransferases of the Golgi apparatus involved in mucin O-Glycan biosynthesis (POC1B-GALNT4, GALNT4, GALNT10 and C1GALT1) (Supplementary Table S3). Here, POC1B is linked to Li-Fraumeni syndrome.