In LSG from SS patients with HFS compared to sicca controls we found 15 downregulated miRNAs targeting 84 genes involved in actin cytoskeleton regulation, such as EZR (ezrin) (Supplementary Table S4), encoding a protein participating in the structural organization of the acinar cell apical pole that is overexpressed and mislocalized in LSG from SS-patients (62). Here, EZR is linked to Hand-foot syndrome.