Additionally, 3-hydroxy-3-methylglutaryl-coenzyme A synthase 1 (HMGCS1), as one of cholesterol biosynthesis genes, is impeded in expression level when utilizing the selective PI3Kbeta inhibitor AZD8186 in PTEN-null triple-negative breast cell lines and tumor xenografts (49). The gene discussed is PIK3CB; the disease is neoplasm.