Consequently, we carried on scrutinizing the correlation between FMI signature and the expression level of TME immunosuppressive factors further, which comprises the pivotal cytokines of immunosuppressive TME, IL-10 and TGF-β (34), Treg marker FOXP3 (35), cancer-associated adipocytes activated marker IL-6 (36), and CAF marker FAP (37). The gene discussed is IL6; the disease is cancer.