Indeed, amyloid P component in serum (APCS) and clustering (CLU), both involved in apoptotic, aging and tumor progression processes (GO:0002673) together with complement cascade molecules such as C5, CFI, C4BPA, CFB (R-HSA-173623) were positively associated to selected features of phenotypic signs of B cell hyperactivation and exhausted T-cells (Supplementary Table 2). The gene discussed is CFI; the disease is neoplasm.