Notably, both human and mouse MSA-specific CD8+ TRM in vitiligo lesion showed higher expression of CD122 on a per cell basis and a higher proportion of CD122 expressing MSA-specific CD8+ TRM compared to host CD8+ TRM, suggesting that targeting CD122 preferentially affects autoreactive T cells while leaving most endogenous T cell populations intact (48). This evidence concerns the gene CD8A and vitiligo.