Whole-exome sequencing of human melanoma tissues and the human melanoma cell line revealed that acquired resistance can result from loss-of-function mutations of IFNGR1, IFNGR2, JAK1, JAK2, STAT1, and IRF3 from the IFN-γ signaling pathway and β2M from antigen presentation pathway (37, 38). This evidence concerns the gene JAK1 and melanoma.