Indeed, CARD9 deletion has been shown to prevent Coxsackievirus B3 (CVB3)-induced acute myocarditis (151), Candida albicans water-soluble extract (CAWS)-induced vasculitis (152), neointima formation of grafted veins (153), as well as TAC- or Angiotensin II (Ang II)-induced cardiac dysfunction, fibrosis, and hypertrophy (85, 154), through attenuation of NF-κB, JNK and p38 MAPKs pathway, and production of various cytokines, such as IL-6, IL-1β, TNF-α, IL-17A, TGF-β, and IFN-γ. This evidence concerns the gene AGT and myocarditis.