Autosomal recessive (AR) CARD9 deficiency has been detected in a variety of immunodeficient patients who are predisposed to invasive fungal diseases (IFD), affecting different organ systems ranging from oral mucosa, subcutaneous tissues, skin, gastrointestinal tract to central nervous system (CNS), including chronic mucocutaneous candidiasis (CMC), Candida meningoencephalitis, deep Dermatophytosis, subcutaneous or disseminated phaeohyphomycosis, cutaneous or invasive Aspergillosis, Exophiala disease, and Corynespora cassiicola infection (8, 122–137). Here, CARD9 is linked to chronic mucocutaneous candidiasis.