CARD9(S12N) mutation facilitates Aspergillus fumigatus (Af)-induced Th2 cell-mediated RelB activation and production of IL-5 in peripheral blood mononuclear cells (PBMCs) from patients with allergic bronchopulmonary aspergillosis (ABPA) (70). This evidence concerns the gene IL5 and allergic bronchopulmonary aspergillosis.