Compared to wild-type (WT) mice, CARD9 deficient mice display an impaired ability to produce local cytokines and a decrease in adaptive responses, and are more susceptible to infections with Rhizopus arrhizus, phaeohyphomycosis, Candida albicans, Cryptococcus neoformans, and Pneumocystis, resulting in elevated fungal burdens and increased mortality (32, 34, 39, 49, 89). The gene discussed is CARD9; the disease is infection.